Patterns of Care for Locally Advanced Pancreatic Adenocarcinoma Using the National Cancer Database.

ABSTRACT:

Objectives

The role of radiotherapy (RT) in locally advanced pancreatic cancer (LAPC) is uncertain. This study examines patterns of care and survival outcomes of LAPC undergoing chemotherapy alone versus chemotherapy plus RT (C + RT).

Methods

The National Cancer Database was queried for nonmetastatic LAPC patients who received chemotherapy alone or C + RT.

Results

Of the 13,695 patients included, 5306 underwent chemotherapy alone and 4971, C + RT. Use of C + RT declined from 2003 to 2011 (73%-53%), whereas chemotherapy alone increased. Of those receiving RT, rates of intensity-modulated radiotherapy (IMRT) increased (27%-72%), whereas 3-dimensional (3D) RT decreased (73%-28%). Unadjusted 1-year overall survival (OS) was longer for versus chemotherapy (45.6% vs 38.7%),

SUBMITTER: Amini A 

PROVIDER: S-EPMC6218950 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature