LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels.

ABSTRACT:

Background

Visceral adiposity indicators and the product of triglyceride and fasting plasma glucose (TyG) index-related parameters are effective surrogate markers for insulin resistance (IR) and are predictors of metabolic syndrome and diabetes mellitus. However, their genetic determinants have not been previously reported. Pleiotropic associations of LIPC variants have been observed in lipid profiles and atherosclerotic cardiovascular diseases. We aimed to investigate LIPC polymorphisms as the genetic determinants of adiposity status, visceral adiposity indicators and TyG index-related parameters.

Methods

A total of 592 participants from Taiwan were genotyped for three LIPC single nucleotide polymorphisms (SNPs).

Results

The LIPC SNPs rs20

SUBMITTER: Teng MS 

PROVIDER: S-EPMC6218991 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature