Quantitative CT analysis using functional imaging is superior in describing disease progression in idiopathic pulmonary fibrosis compared to forced vital capacity.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is chronic fibrosing pneumonia with an unpredictable natural disease history. Functional respiratory imaging (FRI) has potential to better characterize this disease. The aim of this study was to identify FRI parameters, which predict FVC decline in patients with IPF.

Methods

An IPF-cohort (treated with pamrevlumab for 48 weeks) was retrospectively studied using FRI. Serial CT's were compared from 66 subjects. Post-hoc analysis was performed using FRI, FVC and mixed effects models.

Results

Lung volumes, determined by FRI, correlated with FVC (lower lung volumes with lower FVC) (R² = 0.61, p < 0.001). A negative correlation was observed between specific image based airway radius (siRADaw) at total lung capacity (

SUBMITTER: Clukers J 

PROVIDER: S-EPMC6218992 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature