Rationale and pre-clinical evidences for the use of autologous cartilage micrografts in cartilage repair.

ABSTRACT:

Background

The management of cartilage lesions is an open issue in clinical practice, and regenerative medicine represents a promising approach, including the use of autologous micrografts whose efficacy was already tested in different clinical settings. The aim of this study was to characterize in vitro the effect of autologous cartilage micrografts on chondrocyte viability and differentiation and perform an evaluation of their application in racehorses affected by joint diseases.

Materials and methods

Matched human chondrocytes and micrografts were obtained from articular cartilage using Rigenera® procedure. Chondrocytes were cultured in the presence or absence of micrografts and chondrogenic medium to assess cell viability and cell differentiation. For the pre-clinical ev

SUBMITTER: Vigano M 

PROVIDER: S-EPMC6218996 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature