Dose escalation of radiation therapy with or without induction chemotherapy for unresectable locally advanced pancreatic cancer.

ABSTRACT:

Background

Dose escalation of conventionally fractionated radiation therapy (CFRT) above 45-54 Gy has an unclear survival benefit. Prior National Cancer Database (NCDB) analyses have shown improved overall survival with induction chemotherapy (iC) prior to concurrent chemoradiation (CRT) in locally advanced pancreatic cancer. Our study compared dose-escalated CFRT with and without iC.

Methods

The NCDB was queried for primary stage III, cT4 N0-1 M0 LAPC treated with CRT with or without iC (2004-2015). CFRT was stratified by < 55 Gy and ≥ 55 Gy. Cohort iC + CRT and CRT included those with and without iC, respectively. The primary endpoint was overall survival (OS). Kaplan-Meier analysis, Cox proportional hazards method, and propensity score matching were used.

Results

A

SUBMITTER: Ma SJ 

PROVIDER: S-EPMC6219058 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature