Assessing the effect of oral activated vitamin D on overall survival in hemodialysis patients: a landmark analysis.

ABSTRACT:

Background

Patients with end stage renal disease have a high all-cause and cardiovascular mortality. Secondary hyperparathyroidism and vitamin D deficiency are considered part of the mechanism for the excess mortality observed. We aimed to evaluate the relationship between vitamin D use and all-cause mortality.

Methods

In this retrospective cohort study, we included all incident patients who started hemodialysis in Taiwan between 2001 and 2009. Patients were followed from landmark time, i.e., the 360th day from hemodialysis initiation, through the end of 2010 or death. We evaluated the association between activated vitamin D use or not before landmark time and all-cause mortality using conditional landmark analysis with Cox regression. We used group-based trajectory model to

SUBMITTER: Chao JY 

PROVIDER: S-EPMC6219061 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature