An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men.

ABSTRACT:

Background

Gut microbiome characteristics associated with HIV infection are of intense research interest but a deep understanding has been challenged by confounding factors across studied populations. Notably, a Prevotella-rich microbiome described in HIV-infected populations is now understood to be common in men who have sex with men (MSM) regardless of HIV status, but driving factors and potential health implications are unknown.

Results

Here, we further define the MSM-associated gut microbiome and describe compositional differences between the fecal microbiomes of Prevotella-rich MSM and non-MSM that may underlie observed pro-inflammatory properties. Furthermore, we show relatively subtle gut microbiome changes in HIV infection in MSM and women that include an increase in

SUBMITTER: Armstrong AJS 

PROVIDER: S-EPMC6219090 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature