Development and reliability assessment of a new quality appraisal tool for cross-sectional studies using biomarker data (BIOCROSS).

ABSTRACT:

Background

Biomarker-based analyses are commonly reported in observational epidemiological studies; however currently there are no specific study quality assessment tools to assist evaluation of conducted research. Accounting for study design and biomarker measurement would be important for deriving valid conclusions when conducting systematic data evaluation.

Methods

We developed a study quality assessment tool designed specifically to assess biomarker-based cross-sectional studies (BIOCROSS) and evaluated its inter-rater reliability. The tool includes 10-items covering 5 domains: 'Study rational', 'Design/Methods', 'Data analysis', 'Data interpretation' and 'Biomarker measurement', aiming to assess different quality features of biomarker cross-sectional studies. To evaluat

SUBMITTER: Wirsching J 

PROVIDER: S-EPMC6219097 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature