Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida.

ABSTRACT:

Background

Complex multicellularity requires elaborate developmental mechanisms, often based on the versatility of heterodimeric transcription factor (TF) interactions. Homeobox TFs in the TALE superclass are deeply embedded in the gene regulatory networks that orchestrate embryogenesis. Knotted-like homeobox (KNOX) TFs, homologous to animal MEIS, have been found to drive the haploid-to-diploid transition in both unicellular green algae and land plants via heterodimerization with other TALE superclass TFs, demonstrating remarkable functional conservation of a developmental TF across lineages that diverged one billion years ago. Here, we sought to delineate whether TALE-TALE heterodimerization is ancestral to eukaryotes.

Results

We analyzed TALE endowment in the algal radiati

SUBMITTER: Joo S 

PROVIDER: S-EPMC6219170 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature