Analysis of erythrocyte dynamics in Rhesus macaque monkeys during infection with Plasmodium cynomolgi.

ABSTRACT:

Background

Malaria is a major mosquito transmitted, blood-borne parasitic disease that afflicts humans. The disease causes anaemia and other clinical complications, which can lead to death. Plasmodium vivax is known for its reticulocyte host cell specificity, but many gaps in disease details remain. Much less is known about the closely related species, Plasmodium cynomolgi, although it is naturally acquired and causes zoonotic malaria. Here, a computational model is developed based on longitudinal analyses of P. cynomolgi infections in nonhuman primates to investigate the erythrocyte dynamics that is pertinent to understanding both P. cynomolgi and P. vivax malaria in humans.

Methods

A cohort of five P. cynomolgi infected Rhesus macaques (Macaca mulatta) is studied, with ind

SUBMITTER: Fonseca LL 

PROVIDER: S-EPMC6219197 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature