A validated clinical MRI injury scoring system in neonatal hypoxic-ischemic encephalopathy.

ABSTRACT:

Background

Deep nuclear gray matter injury in neonatal hypoxic-ischemic encephalopathy (HIE) is associated with worse neurodevelopmental outcomes. We previously published a qualitative MRI injury scoring system utilizing serial T1-weighted, T2-weighted and diffusion-weighted imaging (DWI), weighted for deep nuclear gray matter injury.

Objectives

To establish the validity of the MRI scoring system with neurodevelopmental outcome at 18-24 months.

Materials and methods

MRI scans from neonates with moderate to severe HIE treated with therapeutic hypothermia were evaluated. Signal abnormality was scored on T1-weighted, T2-weighted and DWI sequences and assessed using an established system in five regions: (a) subcortical: caudate nucleus, globus pallidus and putamen, thala

SUBMITTER: Trivedi SB 

PROVIDER: S-EPMC6219383 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature