An observational study of Chinese adults with relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia.

ABSTRACT: Aim:Chinese adults with relapsed/refractory Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia (Ph- ALL) have poor outcomes. Patients & methods:We conducted a nationwide, retrospective, observational study to assess outcomes in this patient population. Results:Of the 270 enrolled patients, 31% of patients at last salvage achieved complete remission (CR) or CR with partial hematologic recovery (CRh), with median time to CR/CRh of 30 days and median CR/CRh duration of 2.7 months. The CR/CRh rate was more favorable with earlier versus later lines of salvage (41, 24 and 17% at first, second and third or later salvages, respectively). Conclusion:This dataset serves as an important reference of real-world outcomes using currently available chemotherapy regimens for high-risk Chinese adults with relapsed/refractory Ph- ALL.

SUBMITTER: Ma J 

PROVIDER: S-EPMC6219430 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature