Molecular diversification of regulatory T cells in nonlymphoid tissues.

ABSTRACT: Foxp3⁺CD4⁺ regulatory T cells (T_regs) accumulate in certain nonlymphoid tissues, where they control diverse aspects of organ homeostasis. Populations of tissue T_regs, as they have been termed, have transcriptomes distinct from those of their counterparts in lymphoid organs and other nonlymphoid tissues. We examined the diversification of T_regs in visceral adipose tissue, skeletal muscle, and the colon vis-à-vis lymphoid organs from the same individuals. The unique transcriptomes of the various tissue T_reg populations resulted from layering of tissue-restricted open chromatin regions over regions already open in the spleen, the latter tagged by super-enhancers and particular histone marks. The binding motifs for a small numbe

SUBMITTER: DiSpirito JR 

PROVIDER: S-EPMC6219455 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature