Droplet digital PCR quantification of miR-1290 as a circulating biomarker for pancreatic cancer.

ABSTRACT: Droplet digital PCR was used to validate miR-1290 as circulating biomarker for pancreatic cancer (PC). The diagnostic performance of miR-1290 was evaluate in 167 PC patients and 267 healthy subjects at clinical risk of developing the disease (HS). MiR-1290 plasma levels were compared to CA 19-9 determinations, and the combination of the two biomarkers was also taken into account. Plasma levels of miR-1290 were higher in PC patients compared to HS (p = 2.55 × 10^-16). A similar trend was observed for CA 19-9 determinations (p = 1.03 × 10^-47). ROC curve analysis revealed that miR-1290 in combination with CA 19-9 was effective for discriminating between PC patients and HS (AUC = 0.956, 95% CI = 0.933-0.979) than the two biomarkers tested alone (miR-1290: AUC = 0.734, 0.67

SUBMITTER: Tavano F 

PROVIDER: S-EPMC6219528 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature