Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection.

ABSTRACT: Cryptococcus neoformans is an opportunistic fungus that can cause lethal brain infections in immunosuppressed individuals. Infection usually occurs via the inhalation of a spore or desiccated yeast which can then disseminate from the lung to the brain and other tissues. Dissemination and disease is largely influence by the production of copious amounts of cryptococcal polysaccharides, both which are secreted to the extracellular environment or assembled into a thick capsule surrounding the cell body. There are two important polysaccharides: glucuronoxylomannan (GXM) and galactoxylomannan, also called as glucuronoxylomanogalactan (GXMGal or GalXM). Although GXM is more abundant, GalXM has a more potent modulatory effect. In the present study, we show that GalXM is a potent activator of muri

SUBMITTER: LaRocque-de-Freitas IF 

PROVIDER: S-EPMC6219535 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature