Thin Film Multi-Electrode Softening Cuffs for Selective Neuromodulation.

ABSTRACT: Silicone nerve cuff electrodes are commonly implanted on relatively large and accessible somatic nerves as peripheral neural interfaces. While these cuff electrodes are soft (1-50 MPa), their self-closing mechanism requires of thick walls (200-600 µm), which in turn contribute to fibrotic tissue growth around and inside the device, compromising the neural interface. We report the use of thiol-ene/acrylate shape memory polymer (SMP) for the fabrication of thin film multi-electrode softening cuffs (MSC). We fabricated multi-size MSC with eight titanium nitride (TiN) electrodes ranging from 1.35 to 13.95 × 10^-4 cm² (1-3 kΩ) and eight smaller gold (Au) electrodes (3.3 × 10^-5 cm²; 750 kΩ), that soften at physiological conditions to a modulus of 550 MP

SUBMITTER: Gonzalez-Gonzalez MA 

PROVIDER: S-EPMC6219541 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature