Low dietary fiber intake increases Collinsella abundance in the gut microbiota of overweight and obese pregnant women.

ABSTRACT: The gut microbiota contributes to the regulation of glucose metabolism in pregnancy. Abundance of the genus Collinsella is positively correlated with circulating insulin; however, it is unclear what determines Collinsella abundance. This study aims to validate the correlation between Collinsella and insulin and to elucidate if macronutrient intake alters Collinsella abundance and gut microbiota composition. Gut microbiota profiles were assessed by 16S rRNA sequencing in 57 overweight and 73 obese pregnant women from the SPRING (Study of PRobiotics IN Gestational diabetes) trial at 16 weeks gestation and correlated with metabolic hormone levels and macronutrient intake. Gut microbiota composition in the top and bottom 10% of dietary fiber intake was evaluated through network analysis. Colli

SUBMITTER: Gomez-Arango LF 

PROVIDER: S-EPMC6219589 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature