Transposable Element Expression in Acute Myeloid Leukemia Transcriptome and Prognosis.

ABSTRACT: Over half of the human genome is comprised of transposable elements (TE). Despite large-scale studies of the transcriptome in cancer, a comprehensive look at TE expression and its relationship to various mutations or prognosis has not been performed. We characterized the expression of TE in 178 adult acute myeloid leukemia (AML) patients using transcriptome data from The Cancer Genome Atlas. We characterized mutation specific dysregulation of TE expression using a multivariate linear model. We identified distinct patterns of TE expression associated with specific mutations and transcriptional networks. Genes regulating methylation was not associated with significant change in TE expression. Using an unpenalized cox regression analysis we identified a TE expression signature that predicted

SUBMITTER: Colombo AR 

PROVIDER: S-EPMC6219593 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature