Concurrent gut transcriptome and microbiota profiling following chronic ethanol consumption in nonhuman primates.

ABSTRACT: Alcohol use disorder (AUD) results in increased intestinal permeability, nutrient malabsorption, and increased risk of colorectal cancer (CRC). Our understanding of the mechanisms underlying these morbidities remains limited because studies to date have relied almost exclusively on short-term heavy/binge drinking rodent models and colonic biopsies/fecal samples collected from AUD subjects with alcoholic liver disease (ALD). Consequently, the dose- and site-dependent impact of chronic alcohol consumption in the absence of overt liver disease remains poorly understood. In this study, we addressed this knowledge gap using a nonhuman primate model of voluntary ethanol self-administration where rhesus macaques consume varying amounts of 4% ethanol in water for 12 months. Specifically, we perfor

SUBMITTER: Barr T 

PROVIDER: S-EPMC6219653 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature