Brain metastasis DNA methylomes, a novel resource for the identification of biological and clinical features.

ABSTRACT: Brain metastases (BM) are one the most lethal and poorly managed clinical complications in cancer patients. These secondary tumors represent the most common intracranial neoplasm in adults, most frequently originating from lung cancer, breast cancer, and cutaneous melanoma. In primary brain tumors, such as gliomas, recent advances in DNA methylation profiling have allowed for a comprehensive molecular classification. Such data provide prognostic information, in addition to helping predict patient response to specific systemic therapies. However, epigenetic alterations of metastatic brain tumors with specific biological and translational relevance still require much further exploration. Using the widely employed Illumina Infinium HumanMethylation 450K platform, we have generated a cohort of

SUBMITTER: Salomon MP 

PROVIDER: S-EPMC6219670 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature