Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment.

ABSTRACT: Despite the advances in cancer immunotherapy, only a fraction of patients with bladder cancer exhibit responses to checkpoint blockade, highlighting a need to better understand drug resistance and identify rational immunotherapy combinations. However, accessibility to the tumor prior and during therapy is a major limitation in understanding the immune tumor microenvironment (TME). Herein, we identified urine-derived lymphocytes (UDLs) as a readily accessible source of T cells in 32 patients with muscle invasive bladder cancer (MIBC). We observed that effector CD8⁺ and CD4⁺ cells and regulatory T cells within the urine accurately map the immune checkpoint landscape and T cell receptor repertoire of the TME. Finally, an increased UDL count, specifically high expression

SUBMITTER: Wong YNS 

PROVIDER: S-EPMC6219732 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature