ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.

ABSTRACT: A coding variant of the inflammatory bowel disease (IBD) risk gene ATG16L1 has been associated with defective autophagy and deregulation of endoplasmic reticulum (ER) function. IL-22 is a barrier protective cytokine by inducing regeneration and antimicrobial responses in the intestinal mucosa. We show that ATG16L1 critically orchestrates IL-22 signaling in the intestinal epithelium. IL-22 stimulation physiologically leads to transient ER stress and subsequent activation of STING-dependent type I interferon (IFN-I) signaling, which is augmented in Atg16l1 ^ΔIEC intestinal organoids. IFN-I signals amplify epithelial TNF production downstream of IL-22 and contribute to necroptotic cell death. In vivo, IL-22 treatment in Atg16l1 ^ΔIEC and Atg1

SUBMITTER: Aden K 

PROVIDER: S-EPMC6219748 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature