Acute effect of ivabradine on heart rate and myocardial oxygen consumption in dogs with asymptomatic mitral valve degeneration.

ABSTRACT: Degenerative mitral valve disease (DMVD) is a common cardiac disease in geriatric dogs characterized by the degeneration of the mitral valve, leading to decreased cardiac output and activation of the sympathetic and renin-angiotensin-aldosterone system. This disease results in an increased resting heart rate (HR) and myocardial oxygen consumption (MVO₂). A recent publication demonstrated that dogs with asymptomatic DMVD had a significantly higher HR and systemic blood pressure (BP) than age-matched control dogs. This higher HR will eventually contribute to increased MVO₂. This study aimed to determine the effects of a single oral dose of ivabradine on the HR, MVO₂ as assessed by the rate-pressure product, and BP in dogs with asymptomatic DMVD. Seven beagles

SUBMITTER: Pirintr P 

PROVIDER: S-EPMC6219887 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature