Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting.

ABSTRACT:

Background

Maternal vaccines against pertussis are not yet recommended in the developing world. Besides unclear burden estimates, another concern is that transplacental transfer of maternal pertussis antibodies could result in attenuation of the immune response to whole cell pertussis (DTwP) primary vaccination series in infants. This study was taken up to determine whether higher levels of maternal pertussis antibodies attenuate immune response of infants to DTwP vaccination series given at 6-10-14 weeks of age.

Methodology

A total of 261 pregnant women and their infants from four low-income settlements in Karachi, Pakistan were enrolled in this study. The study endpoints were infant antibody titers for Pertussis toxin (PTx), Filamentous hemagglutinin antigen (FHA), Pertact

SUBMITTER: Ibrahim R 

PROVIDER: S-EPMC6219892 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature