Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.

ABSTRACT:

Aims/hypothesis

Ceramides are sphingolipids that contribute to insulin resistance in preclinical studies. We hypothesised that plasma ceramides would be associated with body fat distribution, insulin resistance and incident type 2 diabetes in a multi-ethnic cohort.

Methods

A total of 1557 participants in the Dallas Heart Study without type 2 diabetes underwent measurements of metabolic biomarkers, fat depots by MRI and plasma ceramides by liquid chromatography-mass spectrometry. Diabetes outcomes were assessed after 7 years. Associations of body fat and insulin resistance with ceramides at baseline and of ceramides with incident diabetes outcomes were analysed.

Results

The cohort had a mean age of 43 years, with 58% women, 45% black participants and a mean BMI of 28 k

SUBMITTER: Neeland IJ 

PROVIDER: S-EPMC6219923 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature