Statins attenuate outgrowth of breast cancer metastases.

ABSTRACT:

Background

Metastasis in breast cancer foreshadows mortality, as clinically evident disease is aggressive and generally chemoresistant. Disseminated breast cancer cells often enter a period of dormancy for years to decades before they emerge as detectable cancers. Harboring of these dormant cells is not individually predictable, and available information suggests that these micrometastatic foci cannot be effectively targeted by existing therapies. As such, long-term, relatively non-toxic interventions that prevent metastatic outgrowth would be an advance in treatment. Epidemiological studies have found that statins reduce breast cancer specific mortality but not the incidence of primary cancer. However, the means by which statins reduce mortality without affecting primary tumor dev

SUBMITTER: Beckwitt CH 

PROVIDER: S-EPMC6220112 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature