Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces.

ABSTRACT: Intracortical neural microelectrodes, which can directly interface with local neural microcircuits with high spatial and temporal resolution, are critical for neuroscience research, emerging clinical applications, and brain computer interfaces (BCI). However, clinical applications of these devices remain limited mostly by their inability to mitigate inflammatory reactions and support dense neuronal survival at their interfaces. Herein we report the development of microelectrodes primarily composed of extracellular matrix (ECM) proteins, which act as a bio-compatible and an electrochemical interface between the microelectrodes and physiological solution. These ECM-microelectrodes are batch fabricated using a novel combination of micro-transfer-molding and excimer laser micromachining to exh

SUBMITTER: Shen W 

PROVIDER: S-EPMC6220172 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature