Green tea polyphenols protect against preglomerular arteriopathy via the jagged1/notch1 pathway.

ABSTRACT: Preglomerular arteriopathy (PA) induced by hyperuricemia contributes to the progression of chronic kidney disease (CKD). Green tea polyphenols (GTPs) are antioxidant ingredients thought to assist in preventing hyperuricemia. However, the underlying mechanism by which GTPs affect renal function remains unclear. Both normal and remnant kidney (RK) rats were administrated oxonic acid (OX) to induce hyperuricemia. The hyperuricemia RK rats were concomitantly treated with GTPs. Hematoxlyin-eosin (H&E) and periodic acid-Schiff (PAS) staining methods were used to examine renal function and arterial morphology. The expression of proteins in the Jagged1/Notch1 pathway was assessed via immunohistochemistry, in situ hybridization, the quantitative polymerase chain reaction (qPCR), and western

SUBMITTER: Wang W 

PROVIDER: S-EPMC6220216 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature