Magnetoresistive biosensors with on-chip pulsed excitation and magnetic correlated double sampling.

ABSTRACT: Giant magnetoresistive (GMR) sensors have been shown to be among the most sensitive biosensors reported. While high-density and scalable sensor arrays are desirable for achieving multiplex detection, scalability remains challenging because of long data acquisition time using conventional readout methods. In this paper, we present a scalable magnetoresistive biosensor array with an on-chip magnetic field generator and a high-speed data acquisition method. The on-chip field generators enable magnetic correlated double sampling (MCDS) and global chopper stabilization to suppress 1/f noise and offset. A measurement with the proposed system takes only 20 ms, approximately 50× faster than conventional frequency domain analysis. A corresponding time domain temperature correction technique is also

SUBMITTER: Kim K 

PROVIDER: S-EPMC6220270 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature