Increased frequency of systemic pro-inflammatory Vδ1⁺ γδ T cells in HIV elite controllers correlates with gut viral load.

ABSTRACT: γδ T cells predominate in the intestinal mucosa and help maintain gut homeostasis and mucosal immunity. Although HIV infection significantly alters these cells, what drives these perturbations is unclear. Growing evidence suggests that impaired intestinal immune function in HIV leads to chronic immune activation and disease progression. This occurs even in HIV controllers - individuals with undetectable HIV viremia without antiretroviral therapy (ART). We show that Vδ1⁺ cells, a subset of γδ T cells described as being important in intestinal barrier function, increase in frequency in HIV-infected individuals, including HIV controllers. These cells resemble terminally differentiated effector memory cells, producing the pro-inflammatory cytokines IFNγ, TNFα, and MIP-1β upon stimul

SUBMITTER: Olson GS 

PROVIDER: S-EPMC6220338 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature