Seasonal Genetic Drift of Human Influenza A Virus Quasispecies Revealed by Deep Sequencing.

ABSTRACT: After a pandemic wave in 2009 following their introduction in the human population, the H1N1pdm09 viruses replaced the previously circulating, pre-pandemic H1N1 virus and, along with H3N2 viruses, are now responsible for the seasonal influenza type A epidemics. So far, the evolutionary potential of influenza viruses has been mainly documented by consensus sequencing data. However, like other RNA viruses, influenza A viruses exist as a population of diverse, albeit related, viruses, or quasispecies. Interest in this quasispecies nature has increased with the development of next generation sequencing (NGS) technologies that allow a more in-depth study of the genetic variability. NGS deep sequencing methodologies were applied to determine the whole genome genetic heterogeneity of the three ca

SUBMITTER: Barbezange C 

PROVIDER: S-EPMC6220372 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature