The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review.

ABSTRACT:

Background

Several quinoline and structurally related antimalarial drugs are associated with cardiovascular side effects, particularly hypotension and electrocardiographic QT interval prolongation. A prolonged QT interval is a sensitive but not specific risk marker for the development of Torsade de Pointes-a potentially lethal polymorphic ventricular tachyarrhythmia. The increasing use of quinoline and structurally related antimalarials in mass treatments to eliminate malaria rapidly highlights the need to review their cardiovascular safety profiles.

Methods

The primary objective of this systematic review was to describe the documented clinical and electrocardiographic cardiovascular side effects of quinine, mefloquine, lumefantrine, piperaquine, halofantrine, chloroquine, s

SUBMITTER: Haeusler IL 

PROVIDER: S-EPMC6220451 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature