Alterations of brain local functional connectivity in amnestic mild cognitive impairment.

ABSTRACT:

Background

Resting-state functional magnetic resonance imaging studies using a regional homogeneity (ReHo) method have reported that amnestic mild cognitive impairment (aMCI) was associated with abnormalities in local functional connectivity. However, their results were not conclusive.

Methods

Seed-based d Mapping was used to conduct a coordinate-based meta-analysis to identify consistent ReHo alterations in aMCI.

Results

We identified 10 studies with 11 datasets suitable for inclusion, including 378 patients with aMCI and 435 healthy controls. This meta-analysis identified significant ReHo alterations in patients with aMCI relative to healthy controls, mainly within the default mode network (DMN) (bilateral posterior cingulate cortex [PCC], right angular gyrus

SUBMITTER: Zhen D 

PROVIDER: S-EPMC6220503 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature