Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study.

ABSTRACT:

Background

The contribution of genetic polymorphisms to the large inter-individual variation in mammographic density (MD) changes following starting and stopping use of estrogen and progestin combined therapy (EPT) has not been well-studied. Previous studies have shown that circulating levels of insulin-like growth factors are associated with MD and cross-talk between estrogen signaling and growth factors is necessary for cell proliferation in the breast. We evaluated single nucleotide polymorphisms (SNPs) in growth factor genes in association with MD changes after women stop EPT use.

Methods

We genotyped 191 SNPs in 13 growth factor pathway genes in 284 non-Hispanic white California Teachers Study participants who previously used EPT and collected their mammograms before an

SUBMITTER: Lee E 

PROVIDER: S-EPMC6220514 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature