Physical Activity and Incident Cardiovascular Disease in Women: Is the Relation Modified by Level of Global Cardiovascular Risk?

ABSTRACT: The inverse association between physical activity and cardiovascular disease (CVD) is well- established and has previously been shown in people with and without single CVD risk factors. We examined whether level of global cardiovascular risk, on the basis of the pooled cohort equation or Reynolds risk score, which include multiple risk factors, modified the physical activity-CVD association. Participants in the prospective WHS (Women's Health Study; n=27 536) reported their leisure-time physical activity at study entry (1992-1995) and during follow-up through 2013. Participants were divided into 10-year cardiovascular risk groups on the basis of the pooled cohort equation and Reynolds risk score. The primary outcome was incident total CVD. The CVD hazard ratio for active (≥500 kcal/wk of p

SUBMITTER: Chomistek AK 

PROVIDER: S-EPMC6220541 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature