Implications of the Pattern of Disease Recurrence on Survival Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma.

ABSTRACT:

Background

After radical resection of pancreatic ductal adenocarcinoma (PDAC), approximately 80% of patients will develop disease recurrence. It remains unclear to what extent the location of recurrence carries prognostic significance. Additionally, stratifying the pattern of recurrence may lead to a deeper understanding of the heterogeneous biological behavior of PDAC.

Objective

The aim of this study was to characterize the relationship of recurrence patterns with survival in patients with resected PDAC.

Methods

This single-center cohort study included patients undergoing pancreatectomy at the Johns Hopkins Hospital between 2000 and 2013. Exclusion criteria were neoadjuvant therapy and incomplete follow-up. Sites of first recurrence were stratified into five groups a

SUBMITTER: Groot VP 

PROVIDER: S-EPMC6220676 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature