Ameliorative effects of selenium on the excess apoptosis of the jejunum caused by AFB₁ through death receptor and endoplasmic reticulum pathways.

ABSTRACT: Aflatoxin B₁ (AFB₁), one of most potent and common mycotoxins in human food and animal feed, has hepatotoxic and carcinogenic effects on humans and poultry. Recent studies indicated that selenium (Se) has a protective effect on apoptosis induced by toxin poisoning. The present study was designed to reveal the ameliorative effects of selenium on the expression of apoptosis related molecules in the jejunum of broilers exposed to an AFB₁ diet for 3 weeks. A total of 216 one-day-old healthy Cobb broilers were randomly divided into the control group (0 mg kg^-1 AFB₁), AFB₁ group (0.6 mg kg^-1 AFB₁), AFB₁ + Se group (0.6 mg kg^-1 AFB₁ + 0.4 mg kg^-1 supplement Se) and S

SUBMITTER: Fang J 

PROVIDER: S-EPMC6220717 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature