Urinary metabolomics reveals novel interactions between metal exposure and amino acid metabolic stress during pregnancy.

ABSTRACT: Pregnant women are a unique group undergoing profound structural modifications in uterus, breast, adipose tissue and extracellular fluids. Amino acid metabolic stress is a unique physical process that occurs during pregnancy. Metals constitute a fundamental part of the maternal body and have a universal effect on amino acid metabolism. However, the exact interaction between metals and amino acid metabolism during pregnancy is unknown. The aim of the present study was to determine the correlations of metals with amino acid metabolic intermediates in the urine of 232 healthy pregnant women in their first, second and third trimesters during normal pregnancy. Sixteen metals in the urine of 232 healthy pregnant women in their first, second and third trimesters were quantified using inductively

SUBMITTER: Wang M 

PROVIDER: S-EPMC6220731 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature