Hyperpolarized ¹³ C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.

ABSTRACT: Hyperpolarized MRI with ¹³ C-labeled metabolites has enabled metabolic imaging of tumors in vivo. The heterogeneous nature of tumors and the limited lifetime of the hyperpolarization require high resolution, both temporally and spatially. We describe two sequences that make more efficient use of the ¹³ C polarization than previously described single-shot 3D sequences. With these sequences, the target metabolite resonances were excited using spectral-spatial pulses and the data acquired using spiral readouts from a series of echoes created using a fast-spin-echo sequence employing adiabatic 180° pulses. The third dimension was encoded with blipped gradients applied in an interleaved order to the echo train. Adiabatic inversion pulses applied in the absence of slice sel

SUBMITTER: Wang J 

PROVIDER: S-EPMC6220795 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature