Total Synthesis, Stereochemical Assignment, and Divergent Enantioselective Enzymatic Recognition of Larreatricin.

ABSTRACT: A concise and efficient total synthesis of the lignan natural product larreatricin as well as an unambiguous assignment of configuration of its enantiomers are reported, resolving a long-held controversy. Enzyme kinetic studies revealed that different polyphenol oxidases show high and remarkably divergent enantioselective recognition of this secondary metabolite.

SUBMITTER: Martin HJ 

PROVIDER: S-EPMC6220842 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature