Long-term cognitive trajectories and heterogeneity in patients with schizophrenia and their unaffected siblings.

ABSTRACT:

Objective

This study aimed to assess the heterogeneity and stability of cognition in patients with a non-affective psychotic disorder and their unaffected siblings. In addition, we aimed to predict the cognitive subtypes of siblings by their probands.

Method

Assessments were conducted at baseline, 3 and 6 years in 1119 patients, 1059 siblings and 586 controls from the Genetic Risk and Outcome of Psychosis (GROUP) study. Group-based trajectory modeling was applied to identify trajectories and clustered multinomial logistic regression analysis was used for prediction modeling. A composite score of eight neurocognitive tests was used to measure cognitive performance.

Results

Five stable cognitive trajectories ranging from severely altered to high cognitive performance we

SUBMITTER: Islam MA 

PROVIDER: S-EPMC6220939 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature