Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease.

ABSTRACT:

Background

Misbalances in extracellular matrix turnover are key factors in the development of stricturing (Montreal B2) and penetrating (Montreal B3) Crohn's disease.

Aim

To determine whether serological markers for collagen formation and degradation could serve as biomarkers for complications of Crohn's disease.

Methods

Serum biomarkers for type I, III, V and VI collagen formation (P1NP, Pro-C3, Pro-C5, Pro-C6) and matrix metalloproteinase mediated degradation (C1M, C3M, C5M and C6M) were measured in a retrospective, single centre cohort of 112 patients with Crohn's disease in the terminal ileum (nonstricturing/nonpenetrating: n=40, stricturing: n=55, penetrating: n=17) and 24 healthy controls. Active inflammation was defined as CRP >5 mg/L.

Results

C3M and Pr

SUBMITTER: van Haaften WT 

PROVIDER: S-EPMC6221070 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature