Sustained conduction of vasomotor responses in rat mesenteric arteries in a two-compartment in vitro set-up.

ABSTRACT:

Aim

Conduction of vasomotor responses may contribute to long-term regulation of resistance artery function and structure. Most previous studies have addressed conduction of vasoactivity only during very brief stimulations. We developed a novel set-up that allows the local pharmacological stimulation of arteries in vitro for extended periods of time and studied the conduction of vasomotor responses in rat mesenteric arteries under those conditions.

Methods

The new in vitro set-up was based on the pressure myograph. The superfusion chamber was divided halfway along the vessel into two compartments, allowing an independent superfusion of the arterial segment in each compartment. Local and remote cumulative concentration-response curves were obtained for a range of vasoactive ag

SUBMITTER: Palao T 

PROVIDER: S-EPMC6221078 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature