Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells.

ABSTRACT:

Background

Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To investigate disease processes in accessible patient cells, we studied peripheral blood mononuclear cells in recently diagnosed PD patients and rapid eye movement-sleep behavior disorder patients who have a greatly increased risk of developing PD. We hypothesized that peripheral blood mononuclear cells may recapitulate cellular pathology found in the PD brain and investigated these cells for mitochondrial dysfunction and oxidative stress.

Methods

Peripheral blood mononuclear cells were isolated and studied from PD patients, rapid eye movement-sleep behavior disorder patients and age- and sex-matched control individuals from the w

SUBMITTER: Smith AM 

PROVIDER: S-EPMC6221131 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature