Weight Cycling Increases Longevity Compared with Sustained Obesity in Mice.

ABSTRACT:

Objective

Despite the known health benefits of weight loss among persons with obesity, observational studies have reported that cycles of weight loss and regain, or weight cycling, are associated with increased mortality. To study whether weight loss must be sustained to achieve health and longevity benefits, we performed a randomized controlled feeding study of weight cycling in mice.

Methods

In early adult life, obese mice were randomized to ad libitum feeding to sustain obesity, calorie restriction to achieve a "normal" or intermediate body weight, or weight cycling (repeated episodes of calorie restriction and ad libitum refeeding). Body weight, body composition, and food intake were followed longitudinally until death. A subsample of mice was collected from each group f

SUBMITTER: Smith DL 

PROVIDER: S-EPMC6221135 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature