The clinical features, underlying immunology, and treatment of autoantibody-mediated movement disorders.

ABSTRACT: An increasing number of movement disorders are associated with autoantibodies. Many of these autoantibodies target the extracellular domain of neuronal surface proteins and associate with highly specific phenotypes, suggesting they have pathogenic potential. Below, we describe the phenotypes associated with some of these commoner autoantibody-mediated movement disorders, and outline increasingly well-established mechanisms of autoantibody pathogenicity which include antigen downregulation and complement fixation. Despite these advances, and the increasingly robust evidence for improved clinical outcomes with early escalation of immunotherapies, the underlying cellular immunology of these conditions has received little attention. Therefore, here, we outline the likely roles of T cells and B

SUBMITTER: Damato V 

PROVIDER: S-EPMC6221172 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature