Gametocyte Carriage, Antimalarial Use, and Drug Resistance in Cambodia, 2008-2014.

ABSTRACT: Gametocytes are the malaria parasite stages responsible for transmission from humans to mosquitoes. Gametocytemia often follows drug treatment, especially as therapies start to fail. We examined Plasmodium falciparum gametocyte carriage and drug resistance profiles among 824 persons with uncomplicated malaria in Cambodia to determine whether prevalent drug resistance and antimalarial use has led to a concentration of drug-resistant parasites among gametocyte carriers. Although report of prior antimalarial use increased from 2008 to 2014, the prevalence of study participants presenting with microscopic gametocyte carriage declined. Gametocytemia was more common in those reporting antimalarial use within the past year, and prior antimalarial use was correlated with higher IC₅₀

SUBMITTER: Lin JT 

PROVIDER: S-EPMC6221238 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature