Elimination prospects of the Dutch HIV epidemic among men who have sex with men in the era of preexposure prophylaxis.

ABSTRACT:

Objective

Preexposure prophylaxis (PrEP) is a promising intervention to help end the HIV epidemic among men who have sex with men (MSM) in the Netherlands. We aimed to assess the impact of PrEP on HIV prevalence in this population and to determine the levels of PrEP coverage necessary for HIV elimination.

Design and methods

We developed a mathematical model of HIV transmission in a population stratified by sexual risk behavior with universal antiretroviral treatment (ART) and daily PrEP use depending on an individual's risk behavior. We computed the effective reproduction number, HIV prevalence, ART and PrEP coverage for increasing ART and PrEP uptake levels, and examined how these were affected by PrEP effectiveness and duration of PrEP use.

Results

At current levels

SUBMITTER: Rozhnova G 

PROVIDER: S-EPMC6221378 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature