An ancient Turing-like patterning mechanism regulates skin denticle development in sharks.

ABSTRACT: Vertebrates have a vast array of epithelial appendages, including scales, feathers, and hair. The developmental patterning of these diverse structures can be theoretically explained by Alan Turing's reaction-diffusion system. However, the role of this system in epithelial appendage patterning of early diverging lineages (compared to tetrapods), such as the cartilaginous fishes, is poorly understood. We investigate patterning of the unique tooth-like skin denticles of sharks, which closely relates to their hydrodynamic and protective functions. We demonstrate through simulation models that a Turing-like mechanism can explain shark denticle patterning and verify this system using gene expression analysis and gene pathway inhibition experiments. This mechanism bears remarkable similarity to a

SUBMITTER: Cooper RL 

PROVIDER: S-EPMC6221541 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature