Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer.

ABSTRACT:

Rationale

In lung cancer, upregulation of the PI3K (phosphoinositide 3-kinase) pathway is an early event that contributes to cell proliferation, survival, and tissue invasion. Upregulation of this pathway was recently described as associated with enrichment of the lower airways with bacteria identified as oral commensals.

Objectives

We hypothesize that host-microbe interactions in the lower airways of subjects with lung cancer affect known cancer pathways.

Methods

Airway brushings were collected prospectively from subjects with lung nodules at time of diagnostic bronchoscopy, including 39 subjects with final lung cancer diagnoses and 36 subjects with noncancer diagnoses. In addition, samples from 10 healthy control subjects were included. 16S ribosomal RNA gene amplic

SUBMITTER: Tsay JJ 

PROVIDER: S-EPMC6221574 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature